Ozempic is an injectable subcutaneous medicine used to treat type 2 diabetes once a week. Those with diabetes and heart disease can also use it to lower blood sugar levels and their chance of suffering a significant cardiovascular event, such as a stroke, heart attack, or death. 

It may occasionally be prescribed for weight loss off-label, which means that the F.D.A. hasn't approved it for this usage, even if there is data to support it.

Ozempic is part of a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists, which promote insulin release, inhibiting glucagon's release of glucagon, lowering blood glucose, and delaying the emptying of the stomach. 

The medication is susceptible to extreme temperatures of heat and cold. It needs to be stored under strict conditions. This leads us to the question, does Ozempic need to be refrigerated?

Ozempic comes as a pre-filled pen containing a liquid medication formulation. Before opening, it should be refrigerated at a temperature between 36°F to 46°F (2°C - 8°C). During use, Ozempic pens can be stored for up to 56 days (8 weeks) either at room temperature (not above 30˚C) or in a refrigerator (2˚C to 8˚C), away from the cooling element. Most importantly is that Ozempic® must not be frozen or exposed to heat or direct sunlight.

You must follow the storage instructions provided by the manufacturer to ensure the medication's effectiveness and safety. 

If you have any doubts about storing Ozempic pens or any other medication, it is always best to consult with your pharmacist, healthcare provider, or pharmacist.

What is an Ozempic Pen?

An Ozempic pen is a medical device used for administering the Ozempic (semaglutide) medication to treat type 2 diabetes. 

The pen is a pre-filled, disposable injection device that contains a liquid formulation of Ozempic. It is designed to make it easier for patients to self-administer the medication.

The Ozempic pen has a built-in needle and is available in two dosage strengths: 0.5 mg and 1 mg. The pen is available in a package that includes multiple Ozempic pens, each containing a single dose of medication.

To use the Ozempic pen, the patient typically selects the pen cap and appropriate dose, inserts the needle into the skin, and pushes a button to deliver the medication. 

Per injection, the pen delivers doses of 1mg. Ozempic pens are usually disposed of after use, and a new pen is used for the next injection dose.

How Long Can You Leave Ozempic Unrefrigerated?

For six weeks while in use, you can store your Ozempic pen at room temperature (no higher than 30 °C) or in a refrigerator (2 °C to 8 °C), away from the cooling element. 

Avoid freezing. The medication included in Ozempic should not be frozen, heated, or exposed to sunlight.

If Ozempic has been refrigerated and left unrefrigerated, it should not be used and discarded. Exposure to temperatures outside the recommended range may affect the medication's potency and safety. 

To shield the medication from light, replace the pen cap after each dose of Ozempic. Ozempic should always be protected against high temperatures, even when not stored in the refrigerator. 

Ozempic can be exposed to temperatures above 86°F (30°C). Its effectiveness is no longer assured. When you need to transport your medication and live somewhere that gets hot, you should consider utilizing a medical-grade cooler.

Injecting yourself with bad Ozempic might have serious repercussions. Look at the expiration date on the container to see how long your Ozempic pen is safe before opening to avoid acute kidney injury, acute gallbladder disease, and thyroid c cell tumors. If you find n pain while administering the injection, you might want to hold off until the pen has come to room temperature.

Can You Put the Ozempic Pen in the Freezer?

Ozempic must never be frozen, just like Insulin and Victoza. Ozempic is an aqueous solution; the active component, semaglutide, dissolves in water. 

It freezes and solidifies at 32°F (0°C), much like water. The remedy degrades after being frozen. It doesn't get back to being as effective as it was. 

Ozempic is no longer safe to use once frozen, even if it has since been thawed. Get a new pen right away and throw this one away.

Unused Ozempic pens can be retained until the expiration date listed on the label; however, they must be kept in the refrigerator.

How Can You Tell When Ozempic Has Gone Bad?

Ozempic can expire or go bad if not properly stored, just like any medication. Here are several warning indications that the Ozempic pen may not be suitable for use:


If the liquid in the Ozempic pen appears discolored or cloudy, it may be a sign that the medication has gone bad.

Clumping or particles

If you notice clumping or particles in the liquid, this may also indicate that the medication has gone bad and should not be used.

Unusual odor

If the medication has an unusual or foul odor, it may be a sign that it has gone bad.

Changes in texture

If the liquid appears to have a different texture or consistency than usual, it may be a sign that it has gone wrong.

If you notice any of these signs, it is essential not to use the medication and to dispose of it properly.

Frequently Asked Questions

Does Ozempic make you tired?

Fatigue is a potential side effect of Ozempic (semaglutide), although it does not affect everyone who takes the medication. 

Some people may experience fatigue or weakness during the first few weeks of treatment as their body adjusts to the medication, or they may lose weight. This side effect may disappear as the body adapts to the drug.

It is unclear why the medicine affects body weight in particular people in this way. It might result from Ozempic's ability to reduce appetite, which causes users to eat less and obtain less energy from food.

Other common side effects of Ozempic include nausea, diarrhea, constipation, stomach pain, and decreased appetite. 

In rare cases, Ozempic may cause more serious side effects, such as severe allergic reactions or pancreatitis. Following up regularly with your pharmacist or healthcare provider is important to ensure that the Ozempic is working well for you.

How can I travel with medicine that needs to be refrigerated? 

To travel with medication that needs refrigeration, you should plan and ensure you have enough medication to last your trip. 

Keep the medication cold by using a small cooler bag with ice packs or an insulin medication cooler and placing it in its original packaging in a sealed plastic bag. Avoid freezing the medication and declare it to the T.S.A. if traveling by air. 

Store it properly upon arrival by putting it in the refrigerator as soon as possible. If you are staying in a hotel, you can request a mini-fridge or ask the hotel staff to store it in their refrigerator. 

Following these steps ensures that your Ozempic remains at the proper temperature and is effective during travel.

How do I get the best results with Ozempic?

To get the best results with Ozempic, it is essential to follow the instructions provided by your healthcare provider. This typically involves injecting it once a week on the same day and time. 

The FDA originally approved the injectable pharmaceutical for treating diabetes in 2017. In 2021, the FDA approved Wegovy, a drug with a greater dose of the main ingredient in Ozempic, called Semaglutide, to treat obesity.

Maintaining a healthy lifestyle by following a balanced diet and engaging in regular physical activity can also enhance the medication's effects. Monitoring your blood glucose regularly and attending regular check-ups with your healthcare provider can help track your progress and make necessary adjustments to your treatment plan. 

It may take several weeks to see the full effects of Ozempic, so patience is essential. By following these guidelines, you can improve your overall health and ensure that you get the best results from Ozempic.

There are some drug interactions with Ozempic. You should ensure your doctor knows all your medications, including prescription and over-the-counter drugs, vitamins, herbal and dietary supplements, and over-the-counter and prescription pharmaceuticals.

If you've forgotten to take an Ozempic injection, do it as soon as you remember. If it is almost time for your next dose, skip the dose you missed and administer the subsequent dose at the scheduled time. Do not administer a dose that is twice as much of the medication to make up for a missed dose of Ozempic.


Ozempic is a medication that needs to be refrigerated to maintain its effectiveness. It should be stored in the refrigerator at a temperature between 36°F to 46°F (2°C - 8°C) and should not be frozen. 

If you need to travel with Ozempic, use a small cooler bag with ice packs to keep it cold, declare it to the T.S.A. if traveling by air, and store it properly upon arrival. By following these guidelines, you can help ensure that your Ozempic remains at the proper temperature and maintains its effectiveness. 

Always consult your healthcare provider if you have concerns or questions about adequately storing and using your Ozempic medication.


To ensure that we give you correct, accurate, and relevant information, all articles on Diabetic & Me are backed by verified information from academic research papers, well-known organizations, research institutions, and medical associations.

About the Author

Ely Fornoville

Hi, I'm Ely Fornoville, and I am the founder of Diabetic & Me. Being a type 1 diabetic since 1996, I developed a passion to help people learn more about diabetes. I write about diabetes and share stories from other diabetics around the world. I currently use a Medtronic Guardian 4 CGM and a MiniMed 780G insulin pump with Humalog insulin.

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