Insulin pumps bring welcome relief to people living with diabetes who are tired of constant injections. They closely imitate the functions of the pancreas, releasing insulin in response to changes in blood sugar. 

Omnipod and t:slim are the biggest names in the diabetic management industry. With the recent release of the Omnipod 5 and the t:slim X2 Control-IQ, a comparison of the two is in order. 

We’ll discuss everything you need to know about these two devices, including their features, performance, average cost, and pros and cons. By the end of this article, you can say that an insulin pump is best suited for your needs.  

Key Facts

  • Omnipod is tubeless and pod-based; t:slim is sleek and thin and uses tubing.
  • Omnipod is waterproof; t:slim is not highlighted explicitly for waterproof use.
  • Omnipod can be controlled via PDM or app, and t:slim features Control-IQ for automated insulin delivery.
  • Omnipod pods are single-use and must be replaced every three days; t:slim uses a rechargeable battery.
  • Pros and Cons: Omnipod is discreet, portable, and easy to use, but pods can be bulky; t:slim has advanced technology and is customizable, but the tubing can be cumbersome.

Insulet Omnipod 5: A Brief Overview

Developed by Massachusetts-based medical device company Insulet, the Omnipod 5 is the world’s first tubeless insulin pump with an integrated CGM (Continuous Glucose Monitor). Its tubeless function eliminates the discomfort of inserting a needle under the skin and the inconvenience of disconnecting when exercising or doing sports.

The Insulet Omnipod 5 is the fourth commercially available AID (Auxin-inducible Degron) system, after the MiniMed 670G System, the MiniMed 770G System, and the Tandem Control-IQ system. It was sent off for approval with the FDA on December 23, 2020, and received full clearance on January 28, 2022. 

Upon its release, the Omnipod 5 broke Insulet’s newly set record. The company raked in over $1.3 billion in revenue for the Omnipod 5 alone, an 18% increase from the year prior. To top it off, the CES (Consumer Electronics Show) named the Omnipod 5 an Innovation Award Honoree due to its outstanding design and engineering. 

Unlike previous Omnipod variants with separate controllers, the Omnipod 5 works with a smartphone app. The app is compatible with Android and Apple products, but Insult will send handheld controllers for users without a compatible smartphone. 

The Omnipod 5 allows full customization, giving you greater control of your glucose range. You won’t have to worry about losing or damaging the remote control, as the app can be downloaded on most phones. 

It also allows you to set up eight different programs to be used at varying times daily, further increasing flexibility.

Tandem t:slim X2 Control-IQ

Since its 2016 launch, the Tandem t:slim X2 has seen multiple advancements. It started as a traditional insulin pump but has now evolved to work in tandem with Dexcom G6 CGM, which doesn’t require a finger stick for diabetes treatment decisions or calibration.  

While the Omnipod 5 is the first tubeless insulin pump, the t:slim X2 is the first insulin pump that uses fully automated insulin dosing software. Tandem named this technology Control-IQ.  

Control-IQ is connected to an integrated CGM and an ACE pump to predict glucose levels and adjust delivery accordingly. 

If glucose values are above 160 mg/dL, basal insulin delivery is increased. If the values are below 112.5 mg/dL, it is reduced. Below 70 mg/dL, it stops. The target level can’t be customized to prevent underdosing or overdosing

The t:slim X2 uses a traditional insulin pump setup (pump mechanism, an insulin reservoir, and a cannula tube) and features optional settings for sleep and exercise. These settings change the treatment values to appropriately match the physiologic needs during these activities. 

Like the Omnipod 5, the t:slim X2 comes with a free t:simulator app for controlling the insulin pump using a mobile device. The app displays alarms and pump alerts, insulin therapy data, basal and bolus deliveries, glucose trends, and pump status changes. It automatically uploads all relevant information into the cloud-based t:connect web application.

Omnipod 5 vs t:slim X2: Similarities and Differences

The Omnipod 5 vs. t:slim X2 are top-tier insulin dosing solutions for people with diabetes. They’re two of the world’s most advanced commercially available dosing systems, so choosing between one is like choosing between Samsung and iPhone. Here’s how they compare to each other: 

Notable Features 

The Omnipod 5’s most defining feature is its tubeless functionality. With it, you’ll simply need to stick the pod on your skin and let the Dexcom G6 CGM sensor do its thing. This makes it an excellent option for children, physically active individuals, and those with trypanophobia (fear of needles).  

When turned on, the Activity feature increases the target glucose level to 150 mg/dL within a set period. When the designated period passes, the pump returns to the old target range, which is added by the user. 

Another noteworthy feature is the Omnipod 5 SmartAdjust, an algorithm-based software that recalibrates insulin rates based on glucose levels every five minutes. You can adjust the levels manually or put them in automatic mode with recommended values. 

On the other hand, the t:slim X2 takes pride in its Control-IQ technology. The pump realigns with the Dexcom G6 CGM every five minutes and predicts your blood sugar 30 minutes ahead of time, looking back on its previous measurements. Based on the numbers presented, the pump will increase, decrease, or suspend basal insulin delivery. 

Like the Omnipod, the t:slim X2 has an Activity feature. The Sleep function keeps your blood sugars between 112.5 and 120 mg/dL so you can get a whole night’s sleep without being woken up due to low blood sugar. The Exercise function adjusts sugar levels between 140 and 160 mg/dL and stops when it’s predicted to be less than or equal to 80 mg/dL. 

When the t:slim X2 detects an abnormal increase in glucose levels (180 mg/dL or more), it releases a bolus shot automatically. It does so with a maximum of once per hour.

The t:slim X2 is compatible with children six and older, whereas the Omnipod can be used for children two and older. 

Ease of Use 

The Omnipod 5 doesn’t rely on plastic tubing or cannula, giving it a fair advantage over the t:slim X2 in terms of comfort and ease of use. Its entirely phone-operated operation makes it all the more convenient. 

The Omnipod 5 measures 1.53 Γ— 2.05 Γ— 0.57 inches, making it one of the smallest insulin pods available on the market. It’s controlled through the Omnipod app, Omnipod View, which allows you to monitor your blood glucose in real-time. 

In comparison, the t: slim X2 relies on a plastic cannula to deliver insulin to the body. The cartridge is designed differently from other insulin pump brands. Rather than using a piston to push the insulin up, it uses pressure to draw it into the tubing. This feature allows for a smaller, slimmer pump. 

The t:slim is about an inch bigger than the Omnipod at 3.1 Γ— 2.0 Γ— 0.6 inches, though still small enough to hide under clothes without issues.  

The touchscreen is intuitive and straightforward enough. It eliminates much of the button-pressing and scrolling required to operate a non-touch-screen insulin pump. It includes insulin sensitivity factors, customizable basal rates, and insulin-to-carbohydrate ratios. 

Both the Ominipod and the t:slim are fully rechargeable. The Ominipod lasts up to three days without charge, while the t:slim battery lasts up to seven days without charge (five if CGM is used).  

Units of Insulin 

The Omnipod 5 can hold up to 200 units of insulin, which is more than enough for general use. Depending on the usage, you may need to change the pods once every two days. It requires about 85 to 100 units to work. 

As for the t:slim, it can hold up to 300 units of fast-acting insulin. It should be changed every two to three days to prevent skin infections. 

Delivery and Accuracy 

The Omnipod 5 and the t:slim X2 are relatively new products, so a clear consensus on which insulin pump delivers better accuracy must be made. Though tests are available, limited clinical data support each pump’s claims. 

Both provide consistent insulin delivery, with rare pod failures (less than 90%). However, the t:slim X2 is believed to control glucose levels better than the Omipod. In a randomized control trial, it demonstrated superiority to sensor-augmented therapy. 

Cost and Insurance

The Omnipod 5 and the t:slim X.S. are covered by private insurance companies, Medicare, select Managed Medicaid Programs and State Medicaid. 

At retail pharmacies and stores, a box of 5 Omnipod DASH pods costs between $150 and $400, while a box of 10 can cost up to $800 (though some retailers sell them for far less). The pod lasts two to three days, depending on how many units you use daily. 

The Dexcom G6 system needed to operate the Omnipod retails at $350 to $400. Each box comes with three sensors, which last ten days each. Therefore, you’ll pay between $500 and $1,200 monthly to use the Omnipod 5 insulin pump. 

The out-of-pocket cost of the t:slim X2 ranges between $3,000 to $4,000. This price covers all the supplies, including the Dexcom G6 system. Some plans cover more than 50% of this cost, so it’s worth looking into your insurance options before buying it at this price.  

Pros and Cons of Omnipod 5

Here are the biggest pros and cons of using Omnipod 5: 

 

Pros:

  •  

    Seamless integration with Dexcom G6, one of the most accurate CGM available with a MARD (Mean Absolute Relative Difference) rating of 9%.

  •  

    Wireless, tubeless application.

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    It lets you add up to eight different glucose targets throughout the day.

  •  

    Customizable targets in 10 mg/dL increments, allowing you to shoot small doses of insulin (from 0.0.5).

  •  

    Adapts to a user’s needs after the first two or three pods, with the algorithm making self-adjustments based on the results over nine days.

  •  

    It has a waterproof rating of IP28, which allows it to be submerged in 25 feet of water for up to 60 minutes without damaging the pod.

 

Cons:

  •  

    Max reservoir volume of only 200 units, with a minimum fill amount of 85 units

  •  

    Accompanying Personal Diabetes Manager isn’t waterproof

  •  

    Pod creates a bulging appearance on the skin

  •  

    Doesn’t allow you to refuel or restart the hearth

Pros and Cons of t:slim X2

These are the advantages and disadvantages of using the t:slim over the Omnipod 5: 

 

Pros:

  •  

    Automatically corrects boluses with a 110 mg/dL target, delivering 60% of that value.

  •  

    It doesn’t require fingersticks for calibration or mealtime dosing.

  •  

    The two-way Bluetooth function allows you to integrate the pump into multiple devices, including smartphones and CGM.

  •  

    Available in up to five different infusion sets to meet your unique needs. Some come with an automatic inserter, while others feature a customizable insertion angle with various cannula lengths.

 

Cons:

  •  

    When the Control IQ is on, you won’t be able to set your target blood sugar. This can be an issue for pregnant women, where the target blood sugar needs to be lower than 110 mg/dL.

  •  

    It isn’t waterproof, so you must take it off when swimming or showering.

  •  

    A clip or waist slip belt is required to place the pump, making it slightly more noticeable than the Omnipod 5.

Conclusion

We hope our Omnipod vs t:slim guide helped you choose the insulin pump best suited for you! 

There’s no definitive winner in this comparison; it’s ultimately up to you to decide which device best matches your preferences. They’re both top-of-the-line insulin pumps with near-perfect accuracy and reliability. 

If you value convenience over anything else, the Omnipod 5 is worth considering for its tubeless functionality. If you don’t mind using a cannula, the t:slim is a good choice for its high-level accuracy and automatic calibration.

Sources

At Diabetic Me, we are committed to delivering information that is precise, accurate, and pertinent. Our articles are supported by verified data from research papers, prestigious organizations, academic institutions, and medical associations to guarantee the integrity and relevance of the information we provide. You can learn more about our process and team on the about us page.

  1. Medical Device Network US FDA approves Insulet’s Omnipod 5 Automated Insulin Delivery System
    Source: Medical Device Network
  2. Business Wire Tandem Diabetes Care Announces FDA Clearance of the t:slim X2 Insulin Pump with Control-IQ Advanced Hybrid Closed-Loop Technology
    Source: Business Wire
  3. Taylor & Francis Online A clinical review of the t:slim X2 insulin pump
    Source: Taylor & Francis Online
  4. Tandem Diabetes Care Insulin Infusion Sets to Meet Your Unique Needs
    Source: Tandem Diabetes Care

5 Comments

  1. Sandra Dee on March 20, 2025

    im not convinced about the costs, yeah they talk about cost and insurance but what does that really mean, for someone on a tight budget is this gonna break the bank, sounds like a lot of tech for managing diabetes but what about us who count every penny, does this really worth it

    Reply
  2. Kev T. on February 15, 2025

    hey Ely Fornoville, just read the part about the Omnipod 5 and Tandem t:slim x2 and was wonderin, how easy are these things to use really? i mean i get the whole tech part, can handle my smartphone and smart home gadgets no prob, but i’ve never had to manage something like diabetes care tech. is the learning curve steep? got a family member who might need one and i wanna help them pick the best, but simplicity is key kl

    Reply
    • Mary-Anne Q. on March 7, 2025

      I’ve had some experience with both, and I think for someone familiar with gadgets, neither should be too difficult to master. It’s all about the initial setup and getting used to the routines.

      Reply
    • Rob V. on March 18, 2025

      had a hard time with the touch screen on the t:slim. Prefer something simpler y’know.

      Reply
  3. Clarisse Barbereau on May 4, 2024

    Bonjour, j’ai la tandem t-slim depuis 2 ans et j’en suis satisfaite. AprΓ¨s effectivement la tubulure peut s’avΓ©rer agaΓ§ante, mΓͺme lorsqu’on a l’habitude (je suis sous pompe Γ  tubulure depuis 2014). Pour l’instant je n’en ressens pas le besoin d’en changer.
    Par contre je n’étais pas au courant qu’il existait une application pour smartphone, merci du tuyau, je vais la tester !

    Reply

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About the Author

Ely Fornoville

Living with type 1 diabetes since 1996 has shaped who I am and fueled my passion for helping others navigate their own diabetes journey. As the founder of Diabetic Me, I share insights, tips, and stories from fellow diabetics around the world. With the Medtronic Guardian 4 CGM and MiniMed 780G insulin pump by my side, I strive to empower others to manage their diabetes and live life to the fullest.

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